Associate Director or Senior Scientist, Computational Chemistry

必須

• PhD degree in Chemistry or equivalent
• Ideally 5+ years of experience in industry (pharma/biotech) drug discovery experience required

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Job Description

• Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Associate Director/Senior Scientist, Computational Chemistry in Fujisawa, Kanagawa, Japan.

OBJECTIVES/PURPOSE

• Work as part of a multi-disciplinary team of computational chemists, medicinal chemists, structural biologists, data scientists, pharmacologists and biologists and provide computational expertise to advance drug discovery projects.
• Contribute to drug discovery efforts across various modalities including small molecules, PROTACs, RNA inhibitors, peptides, and more.
• Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts.

Senior Scientist

• Independently design and execute computational strategies for drug discovery projects
• Contribute as a key scientific expert within one or more project teams
• Develop and apply innovative computational methodologies to solve project challenges
• Influence project decisions through data-driven insights
• Mentor junior scientists and contribute to scientific excellence

Associate Director

• Provide scientific and strategic leadership across multiple drug discovery projects
• Shape computational chemistry strategies and influence portfolio-level decisions
• Drive adoption of emerging technologies (e.g., AI/ML, generative chemistry) across projects
• Act as a thought leader to project teams and senior stakeholders
• Influence cross-functional teams without direct line management authority
• Mentor and elevate scientific capabilities across the organization

Technical/Functional (Line) Expertise

• Expertise in a variety of computational tools and methodology including generative chemistry, large-scale virtual screening, molecular dynamics, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics and more.
• Significant industry experiences contributing as a computational chemist on drug discovery projects against several therapeutic arias and a variety of drug discovery targets (GPCRs, Kinases, Ion channel etc.).
• Strong impact in progressing discovery projects from hits to clinical leads
• Familiarity with organic and synthetic chemistry concepts.
• Provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints.
• Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery.
• Proficiency with state-of-the-art Computational Chemistry software.

Leadership

• Scientific leadership within project teams
• Mentors junior scientists
• Contributes to method development and innovation
• Influences direction across teams and functions
• Drives innovation and capability building at scale

Interaction

• Collaborate with cross-functional global teams
• Present findings to internal stakeholders
• Engage with senior leadership and external partners as needed